Date Name Title Filing Type Shares Traded Price Total Held
Jul 02, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 28,290 $310.14 20,859,531
Nov 26, 2012
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 28,507 $175.12 178,826
Oct 23, 2014
SVP Administration & Asst Secr
SVP Administration & Asst Secr Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 28,523 $391.93 89,890
Aug 25, 2017
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 28,586 $479.93 23,840,429
Oct 17, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Open market or private sale of non-derivative or derivative security 28,656 $18.00 63,009
Jul 11, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 28,662 $314.19 21,858,104
Dec 14, 2010
SVP Clinical Development
SVP Clinical Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 28,736 -- 28,736
Feb 13, 2012
SVP Research and Development S
SVP Research and Development S Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 28,869 $113.35 88,745
Dec 16, 2015
SVP Finance & CFO
SVP Finance & CFO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 28,900 -- 28,900
Dec 16, 2015
SVP General Counsel and Secret
SVP General Counsel and Secret Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 28,900 -- 28,900

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.