Date Name Title Filing Type Shares Traded Price Total Held
Nov 17, 2014
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Bona fide gift 24,900 -- 369,093
Nov 23, 2012
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 312,500 $19.43 369,446
Dec 12, 2019
Director, President and CSO
Director, President and CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 49,405 $377.16 371,876
Jun 28, 2006
Director
Director Form 4 Bona fide gift 17,309 -- 373,176
May 21, 2020
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 13,268 $564.62 374,219
Dec 11, 2023
Director, Bd. Co-Chair, President & CEO
Director, Bd. Co-Chair, President & CEO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 12,841 $844.09 374,429
Dec 31, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 376,861
Sep 18, 2013
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 312,500 $13.00 378,259
Feb 14, 2012
Director, President & CEO
Director, President & CEO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 95,016 $111.01 379,002
May 20, 2020
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 39,974 $570.97 382,419

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.