Date Name Title Filing Type Shares Traded Price Total Held
Dec 17, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 400,000
Feb 16, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 400,000 -- 400,000
Dec 16, 2014
Director, President & CEO
Director, President & CEO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 240,000 -- 400,000
Jun 21, 2018
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 300 $335.01 400,047
Aug 20, 2018
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 210 $21.25 400,057
Jul 10, 2018
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 100 $370.17 400,147
Jul 10, 2018
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 13,194 $369.41 400,247
Jun 21, 2018
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 500 $333.15 400,347
Dec 27, 2005
Director
Director Form 5 Bona fide gift 14,874 -- 400,550
Jun 21, 2018
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 1,300 $332.80 400,847

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.