Date Name Title Filing Type Shares Traded Price Total Held
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 130,714 $483.25 750,224
May 01, 2024
Director, Bd. Co-Chair, President & CSO
Director, Bd. Co-Chair, President & CSO Form 4 Other acquisition or disposition -- -- 752,486
Jan 04, 2024
Director, Bd. Co-Chair, President & CSO
Director, Bd. Co-Chair, President & CSO Form 4 Other acquisition or disposition -- -- 752,486
Dec 11, 2023
Director, Bd. Co-Chair, President & CSO
Director, Bd. Co-Chair, President & CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 12,841 $844.09 752,486
Feb 19, 2019
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 150,722 -- 753,316
Dec 11, 2023
Director, Bd. Co-Chair, President & CSO
Director, Bd. Co-Chair, President & CSO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,155 -- 765,327
Dec 13, 2017
Director, President & CSO
Director, President & CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 11,124 $385.08 775,662
Dec 13, 2017
Director, President & CSO
Director, President & CSO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 195,438 $21.92 786,786
Feb 15, 2024
Director, Bd. Co-Chair, President & CSO
Director, Bd. Co-Chair, President & CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 123,601 $953.83 801,608
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 86,096 $483.25 822,207

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.