Date Name Title Filing Type Shares Traded Price Total Held
Dec 12, 2019
Director, President and CSO
Director, President and CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 77,767 $377.16 444,109
Nov 25, 2019
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 5,994 $362.75 26,461
Nov 22, 2019
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 23,989 $358.33 362,727
May 24, 2019
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 80,164 $313.64 388,505
May 13, 2019
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 15,147 $304.20 32,303
Dec 19, 2018
VP Controller
VP Controller Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 1,602 $364.42 8,269
Dec 13, 2018
Director, President & CEO
Director, President & CEO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 96,079 $377.31 363,014
Dec 13, 2018
Director, President & CEO
Director, President & CEO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 64,052 $377.31 423,962
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 76,863 $377.31 73,137
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 48,192 $377.31 118,993

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.