UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               (AMENDMENT NO. 3)*

                         REGENERON PHARMACEUTICALS, INC.
                                 (Name of Issuer)

                          COMMON STOCK, $.001 PAR VALUE
                         (Title of Class of Securities)

                                   00075886F1
                                  (CUSIP Number)

                                             with a copy to:
     George A. Vandeman, Esq.                Michael W. Sturrock, Esq.
     Senior Vice President,                  Latham & Watkins
     General Counsel and Secretary           633 West Fifth Street
     Amgen Inc.                              Suite 4000
     Amgen Center                            Los Angeles, California  90071
     1840 DeHavilland Drive                  (213) 485-1234
     Thousand Oaks, CA  91320-1789
     (805) 447-1000

                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)


                                March 4, 1996
                      (Date of Event which Requires Filing
                               of this Statement)
If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d- 1(b)(3) or (4), check the following box / /.

Check the following box if a fee is being paid with the statement. / / (A fee is
not required only if the reporting person: (1) has a previous statement on file
reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)

NOTE:  Six copies of this statement, including all exhibits, should be filed
with the Commission.  SEE Rule 13d-1(a) for other parties to whom copies are to
be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on  this form with respect to the subject class of securities,
and for any subsequent amendment  containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).








                                  SCHEDULE 13D


  CUSIP No. 00075886F1                        Page 2 of 5 Pages

- --------------------------------------------------------------------------------
     1   NAME OF PERSON
           AMGEN INC.
- --------------------------------------------------------------------------------
     2   CHECK THE APPROPRIATE BOX IF MEMBER OF A GROUP*   (a)     / /
                                                           (b)     / /
- --------------------------------------------------------------------------------
     3   SEC USE ONLY
- --------------------------------------------------------------------------------
     4   SOURCE OF FUNDS*
           WC
- --------------------------------------------------------------------------------
     5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS           / /
         REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
- --------------------------------------------------------------------------------
     6   CITIZENSHIP OR PLACE OF ORGANIZATION
           DELAWARE
- --------------------------------------------------------------------------------
                     7    SOLE VOTING POWER
                            1,438,766
- --------------------------------------------------------------------------------
 NUMBER OF SHARES    8    SHARED VOTING POWER
 BENEFICIALLY               N/A
 OWNED BY EACH     -------------------------------------------------------------
 REPORTING PERSON    9    SOLE DISPOSITIVE POWER
 WITH                       1,438,766
                   -------------------------------------------------------------
                    10    SHARED DISPOSITIVE POWER
                            N/A
- --------------------------------------------------------------------------------
    11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
         REPORTING PERSON
           1,438,766
- --------------------------------------------------------------------------------
    12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)             / /
         EXCLUDES CERTAIN SHARES*
           N/A
- --------------------------------------------------------------------------------
    13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           8.3%
- --------------------------------------------------------------------------------
    14   TYPE OF PERSON REPORTING*
           CO
- --------------------------------------------------------------------------------
                * SEE INSTRUCTIONS BEFORE FILLING OUT







          This Amendment No. 3 to Schedule 13D is being filed by Amgen Inc., a
Delaware corporation (the "Reporting Person"), to amend the Schedule 13D filed
on July 26, 1995, as amended by Amendment No. 1 filed on September 25, 1995
and Amendment No. 2 filed on December 6, 1995 (the "Schedule 13D"), relating to
the common stock, $.001 par value per share (the "Common Stock") of Regeneron
Pharmaceuticals, Inc. (the "Issuer").  Unless otherwise indicated, all
capitalized terms used herein but not defined herein shall have the meaning
assigned to them in the Schedule 13D.

ITEM 4.   PURPOSE OF TRANSACTION.

          Item 4 to Schedule 13D is hereby amended and supplemented to add the
following information:

          On March 4, 1996, the Reporting Person filed a notice, pursuant to
the Hart-Scott-Rodino Antitrust Improvement Act of 1976, as amended (the
"Act"), seeking clearance to purchase, subject to the Standstill Restrictions
described in the Schedule 13D (one of which generally prohibits the Reporting
Person from acquiring more than 20% of the outstanding shares of capital
stock of the Issuer) and depending on general market and economic conditions
affecting the Issuer and other relevant factors, additional shares of Common
Stock of the Issuer from time to time in open market transactions, private
transactions or otherwise; provided, however, that the shares of Common Stock
to be acquired together with shares of the capital stock of the Issuer
presently owned by the Reporting Person shall not exceed an aggregate of 25%
of the outstanding voting securities of the Issuer.  Such purchases, if any,
which may be made by the Reporting Person following receipt of clearance
under the Act will be for investment purposes.

          Subject to the receipt of clearance under the Act and the
Standstill Restrictions and depending on general market and economic
conditions affecting the Issuer and other relevant factors, the Reporting
Person may purchase additional shares of Common Stock or dispose of some or
all of its shares of Common Stock from time to time in open market
transactions, private transactions or otherwise.

          Except as set forth in the Schedule 13D, the Reporting Person has no
present plans or proposals with respect to any material change in the Issuer's
business or corporate structure or which relate to or would result in:

               (1)  the acquisition by any person of additional securities of
     the Issuer, or the disposition of securities of the Issuer;

               (2)  an extraordinary corporate transaction, such as a merger,
     reorganization or liquidation, involving the Issuer or any of its
     subsidiaries;

               (3)  a sale or transfer of a material amount of assets of the
     Issuer or any of its subsidiaries;

               (4)  any change in the present board of directors or management
     of the Issuer, including any plans or proposals to change the number or
     term of directors or to fill any existing vacancies on the board;

               (5)  any material change in the present capitalization or
     dividend policy of the Issuer;

               (6)  changes in the Issuer's charter, bylaws or instruments
     corresponding thereto or other actions which may impede the acquisition of
     control of the Issuer by any person;

               (7)  causing a class of securities of the Issuer to be delisted
     from a national securities exchange or cease to be authorized to be quoted
     in an inter-dealer quotation system of a registered national securities
     association;

               (8)  a class of equity securities of the Issuer becoming eligible
     for termination of registration pursuant to Section 12(g)(4) of the
     Securities Exchange Act of 1934; or

               (9)  any action similar to any of those enumerated above.

ITEM 5.   INTEREST IN SECURITIES OF THE ISSUER.

          Paragraphs (a) through (e) of Item 5 to Schedule 13D are hereby
amended and restated in their entirety as follows:

          (a) As of the close of business on March 4, 1996, the Reporting
Person beneficially owned 1,438,766 shares of Common Stock (which includes
788,766 shares of Common Stock issuable if and when the shares of Class A
Stock are converted into shares of Common Stock). Such shares of Common Stock
constitute approximately 8.3% of the total number of shares of Common Stock
outstanding as of March 4, 1996, assuming the conversion of the shares of
Class A Stock beneficially owned by the Reporting Person into shares of
Common Stock, and based upon 16,445,931 shares of Common Stock outstanding as
of November 10, 1995 as set forth in the Issuer's Form 10-Q filed with the
Securities and Exchange Commission on November 14, 1995.

          (b)  The Reporting Person has the sole power to vote or to direct the
vote, and the sole power to dispose or to direct the disposition of, the Shares
beneficially owned by the Reporting Person.

          (c)  Not applicable.



                               PAGE 3 OF 5 PAGES





          (d)  Not applicable.

          (e)  Not applicable.



                                PAGE 4 OF 5 PAGES






                                    SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this amendment is true, complete and
correct.


                              AMGEN INC.



                              By:  \s\ George A. Vandeman
                                    ---------------------------------------
                                    Name:    George A. Vandeman
                                    Title:   Senior Vice President, General
                                             Counsel and Secretary









Dated:  March 5, 1996




                                 Page 5 of 5 Pages