Date Name Title Filing Type Shares Traded Price Total Held
Dec 19, 2005
SVP Fin & Admin, CFO, & Treas
SVP Fin & Admin, CFO, & Treas Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 57,818 -- 57,818
Dec 19, 2005
VP, Gen Counsel & Secretary
VP, Gen Counsel & Secretary Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 13,184 -- 13,184
Dec 19, 2005
VP, Gen Counsel & Secretary
VP, Gen Counsel & Secretary Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 26,816 -- 26,816
Dec 19, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 16,463 -- 16,463
Dec 19, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 13,537 -- 13,537
Dec 19, 2005
SVP, Manuf & Process Sciences
SVP, Manuf & Process Sciences Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 17,182 -- 17,182
Dec 19, 2005
SVP, Manuf & Process Sciences
SVP, Manuf & Process Sciences Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 57,818 -- 57,818
Dec 19, 2005
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 250,000 -- 250,000
Dec 19, 2005
SVP, PreclinDevel & Biomol Sci
SVP, PreclinDevel & Biomol Sci Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 17,182 -- 17,182
Dec 19, 2005
SVP, PreclinDevel & Biomol Sci
SVP, PreclinDevel & Biomol Sci Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 82,818 -- 82,818

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.