INVESTORS & MEDIA

Dr. Goldstein has been a director of the company since 1991. He has been a professor of molecular genetics and internal medicine and the chair of the Department of Molecular Genetics at the University of Texas Southwestern Medical Center at Dallas since 1977. Dr. Goldstein is a member of the National Academy of Sciences, the National Academy of Medicine and the Royal Society of London. He also is a member of the boards of trustees of The Rockefeller University and the Howard Hughes Medical Institute. Drs. Goldstein and Brown jointly received the Nobel Prize for Physiology or Medicine in 1985 and the U.S. National Medal of Science in 1988.