| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Apr 14, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 2 | $517.99 | 16,875 |
| Apr 14, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 267 | $518.54 | 16,608 |
| Apr 14, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 422 | $519.85 | 16,186 |
| Apr 14, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 2,096 | $520.43 | 14,090 |
| Apr 14, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 1,595 | $521.32 | 12,495 |
| Apr 14, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 758 | $522.37 | 11,737 |
| Apr 14, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 357 | $524.26 | 11,380 |
| Apr 13, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 13,079 | $52.03 | 24,459 |
| Apr 13, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 7,582 | $511.56 | 16,877 |
| Apr 13, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 13,079 | -- | 25,000 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.