| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 490 | $444.65 | 19,056 |
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 120 | $445.91 | 18,936 |
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 240 | $448.86 | 18,696 |
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 236 | $449.53 | 18,460 |
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 125 | $450.10 | 18,335 |
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 233 | $451.47 | 18,102 |
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 130 | $452.08 | 17,972 |
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 113 | $453.45 | 17,859 |
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 102 | $454.58 | 17,757 |
| Feb 27, 2020 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 2,967 | $455.56 | 14,790 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.