| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Jun 21, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 20,000 | $30.63 | 43,950 |
| Jun 21, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 1,201 | $510.02 | 42,749 |
| Jun 21, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 10,493 | $510.02 | 32,256 |
| Jun 21, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 20,000 | -- | 26,736 |
| Jun 16, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Other acquisition or disposition | -- | -- | 10,000 |
| Jun 16, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Other acquisition or disposition | -- | -- | 5,000 |
| Jun 16, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Other acquisition or disposition | -- | -- | 5,647 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 500 | $462.72 | 32,017 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 100 | $463.91 | 31,917 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 400 | $464.69 | 31,517 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.