| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 1,244 | $465.49 | 30,273 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 185 | $466.52 | 30,088 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 300 | $467.82 | 29,788 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 900 | $468.63 | 28,888 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 2,212 | $469.53 | 26,676 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 2,426 | $470.57 | 24,250 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 100 | $471.15 | 24,150 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 100 | $472.95 | 24,050 |
| Jun 15, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 100 | $474.48 | 23,950 |
| Jun 14, 2017 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 20,295 | $21.25 | 44,245 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.