| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 3,044 | $609.62 | 72,023 |
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 3,931 | $610.49 | 68,092 |
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 2,022 | $611.44 | 66,070 |
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 2,076 | $612.43 | 63,994 |
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 3,218 | $613.49 | 60,776 |
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 4,112 | $614.35 | 56,664 |
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 1,610 | $615.49 | 55,054 |
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 535 | $616.40 | 54,519 |
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 424 | $617.43 | 54,095 |
| Aug 05, 2022 |
EVP Research and Development
|
EVP Research and Development | Form 4 | Open market or private sale of non-derivative or derivative security | 521 | $618.27 | 53,574 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.