| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Aug 16, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 2,302 | $626.10 | 887,483 |
| Aug 13, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 773 | $625.00 | 936,710 |
| Aug 06, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Other acquisition or disposition | -- | -- | 5,848 |
| Aug 05, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 50,000 | $600.06 | 937,483 |
| Jun 24, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Bona fide gift | 211,585 | -- | 213,693 |
| Jun 24, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Bona fide gift | 211,585 | -- | -- |
| Jun 23, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Other acquisition or disposition | -- | -- | 987,483 |
| Jun 23, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Other acquisition or disposition | -- | -- | 5,845 |
| Jun 23, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Other acquisition or disposition | -- | -- | 211,585 |
| Jun 21, 2021 |
Director, President and Chief Scientific
|
Director, President and Chief Scientific | Form 4 | Open market or private sale of non-derivative or derivative security | 738 | $532.89 | 81,370 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.