| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Dec 13, 2013 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 40,000 | -- | 40,000 |
| Jan 10, 2013 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Other acquisition or disposition | -- | -- | 1,532 |
| Jan 09, 2013 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 752 | $21.25 | 15,742 |
| Jan 09, 2013 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 5,000 | $16.80 | 20,742 |
| Jan 09, 2013 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 5,000 | -- | -- |
| Jan 09, 2013 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 752 | -- | 4,705 |
| Jan 04, 2013 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Other acquisition or disposition | -- | -- | 1,532 |
| Jan 03, 2013 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Open market or private sale of non-derivative or derivative security | 786 | $180.83 | 27,790 |
| Jan 03, 2013 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Open market or private sale of non-derivative or derivative security | 6,200 | $181.51 | 21,590 |
| Jan 03, 2013 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Open market or private sale of non-derivative or derivative security | 2,300 | $182.29 | 19,290 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.