| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Dec 19, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Open market or private sale of non-derivative or derivative security | 2,200 | $178.33 | 24,469 |
| Dec 19, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Open market or private sale of non-derivative or derivative security | 1,000 | $179.56 | 23,469 |
| Dec 19, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Open market or private sale of non-derivative or derivative security | 1,256 | $180.62 | 22,213 |
| Dec 19, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Open market or private sale of non-derivative or derivative security | 100 | $181.25 | 22,113 |
| Dec 19, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Open market or private sale of non-derivative or derivative security | 500 | $183.13 | 21,613 |
| Dec 18, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 8,000 | $52.03 | 22,990 |
| Dec 18, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 2,330 | $178.62 | 20,660 |
| Dec 18, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 2,612 | $178.62 | 18,048 |
| Dec 18, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 16,000 | $30.63 | 34,048 |
| Dec 18, 2012 |
SVP Clin Devel & Reg Affairs
|
SVP Clin Devel & Reg Affairs | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 2,743 | $178.62 | 31,305 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.