| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Jul 25, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 5,994 | $126.76 | 22,163 |
| Jul 25, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 15,000 | -- | 15,000 |
| Feb 23, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Other acquisition or disposition | -- | -- | 1,532 |
| Feb 22, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 4,200 | $94.71 | 60,198 |
| Feb 22, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 10,800 | $95.46 | 49,398 |
| Feb 22, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 23,454 | $96.45 | 25,944 |
| Feb 22, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 9,600 | $97.58 | 16,344 |
| Feb 22, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 1,200 | $98.05 | 15,144 |
| Feb 21, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 49,428 | $15.64 | 64,572 |
| Feb 21, 2012 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 7,705 | $100.32 | 56,867 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.