| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Jan 02, 2015 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 1,642 | $415.20 | 12,911 |
| Jan 02, 2015 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 900 | $416.75 | 12,011 |
| Jan 02, 2015 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 1,000 | $417.44 | 11,011 |
| Jan 02, 2015 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 300 | $418.40 | 10,711 |
| Dec 31, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 25,000 | $52.03 | 35,711 |
| Dec 31, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 3,151 | $412.78 | 32,560 |
| Dec 31, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 | 11,027 | $412.78 | 21,533 |
| Dec 31, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 25,000 | -- | 37,079 |
| Dec 22, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Other acquisition or disposition | -- | -- | 18,000 |
| Dec 22, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Other acquisition or disposition | -- | -- | 1,621 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.