| Date | Name | Title | Filing | Type | Shares Traded | Price | Total Held |
|---|---|---|---|---|---|---|---|
| Dec 19, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 3,264 | $30.63 | 10,711 |
| Dec 19, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 | 3,264 | -- | -- |
| Dec 16, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 48,000 | -- | 62,079 |
| Dec 16, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Grant, award or other acquisition pursuant to Rule 16b-3(d) | 34,000 | -- | 34,000 |
| Jan 03, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Other acquisition or disposition | -- | -- | 1,589 |
| Jan 02, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 3,000 | $272.88 | 43,115 |
| Jan 02, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 5,602 | $273.77 | 37,513 |
| Jan 02, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 3,777 | $274.69 | 33,736 |
| Jan 02, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 6,893 | $276.04 | 26,843 |
| Jan 02, 2014 |
SVP Clinical Development & Reg
|
SVP Clinical Development & Reg | Form 4 | Open market or private sale of non-derivative or derivative security | 1,296 | $276.75 | 25,547 |
* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.