Date Name Title Filing Type Shares Traded Price Total Held
Dec 15, 2004
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 11,188 -- 11,188
Dec 15, 2004
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 18,812 -- 18,812
Dec 15, 2004
SVP, Manuf & Process Sciences
SVP, Manuf & Process Sciences Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 10,537 -- 10,537
Dec 15, 2004
SVP, Manuf & Process Sciences
SVP, Manuf & Process Sciences Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 64,463 -- 64,463
Dec 15, 2004
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 31,611 -- 31,611
Dec 15, 2004
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 218,389 -- 218,389
Dec 15, 2004
SVP, PreclinDevel & Biomol Sci
SVP, PreclinDevel & Biomol Sci Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 10,537 -- 10,537
Dec 15, 2004
SVP, PreclinDevel & Biomol Sci
SVP, PreclinDevel & Biomol Sci Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 89,463 -- 89,463
Dec 15, 2004
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 42,148 -- 42,148
Dec 15, 2004
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 270,352 -- 270,352

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.