Insider Transactions

Date	Name	Title	Filing	Type	Shares Traded	Price	Total Held
Aug 13, 2003	BROWN MICHAEL S Director Trans History: 484	Director	Form 4	Conversion of derivative security	2,700	--	2,700
Aug 13, 2003	BROWN MICHAEL S Director Trans History: 484	Director	Form 4	Bona fide gift	2,700	--	--
Aug 13, 2003	BROWN MICHAEL S Director Trans History: 484	Director	Form 4	Conversion of derivative security	2,700	--	--
Jul 28, 2003	VAGELOS P ROY Director Trans History: 742	Director	Form 4	Bona fide gift	5,762	$14.92	308,586
Jun 26, 2003	VAGELOS P ROY Director Trans History: 742	Director	Form 4	Bona fide gift	5,332	$15.89	314,348
Jun 26, 2003	VAGELOS P ROY Director Trans History: 742	Director	Form 4	Bona fide gift	13,237	$15.89	614,277
May 07, 2003	SHOOTER ERIC M Director Trans History: 368	Director	Form 4	Bona fide gift	3,000	$6.72	79,911
Jan 13, 2003	STAHL NEIL SVP, PreclinDevel & Biomol Sci Trans History: 683	SVP, PreclinDevel & Biomol Sci	Form 4	Bona fide gift	250	$19.65	15,482

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.