Date Name Title Filing Type Shares Traded Price Total Held
Oct 02, 2006
SVP, Clinical Development
SVP, Clinical Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,572 -- 25,572
Oct 02, 2006
SVP, Clinical Development
SVP, Clinical Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 74,428 -- 74,428
Sep 27, 2006
Director
Director Form 4 Bona fide gift 13,534 -- 359,642
Sep 15, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 900
Sep 15, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 900
Sep 15, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 1,710,790
Sep 15, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 29,275
Sep 15, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 29,275
Sep 13, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Open market or private sale of non-derivative or derivative security 12,900 $16.52 97,758
Sep 13, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Open market or private sale of non-derivative or derivative security 200 $16.54 97,458

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.