Date Name Title Filing Type Shares Traded Price Total Held
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 400 $10.56 10,047
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Open market or private sale of non-derivative or derivative security 400 $20.15 9,647
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 48 $10.56 9,695
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Open market or private sale of non-derivative or derivative security 48 $20.16 9,647
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 $9.50 19,647
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Open market or private sale of non-derivative or derivative security 10,000 $20.05 9,647
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 -- --
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 24,226 -- 7,463
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 3,100 -- 4,363
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 900 -- 3,463

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.