Insider Transactions

Date Name Title Filing Type Shares Traded Price Total Held
Dec 20, 2007
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 7,741 $22.28 71,710
Dec 20, 2007
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 37,370 -- --
Dec 19, 2007
Director
Director Form 4 Bona fide gift 500 -- 2,975
Dec 19, 2007
SVP Fin & Admin, CFO, & Treas
SVP Fin & Admin, CFO, & Treas Form 4 Other acquisition or disposition -- -- 4,028
Dec 19, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Other acquisition or disposition -- -- 10,414
Dec 19, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Other acquisition or disposition -- -- 2,798
Dec 19, 2007
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 4,028
Dec 19, 2007
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 900
Dec 19, 2007
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 1,710,790
Dec 19, 2007
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 29,275

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.