Insider Transactions

Date Name Title Filing Type Shares Traded Price Total Held
Dec 17, 2007
SVP, Gen Counsel & Secretary
SVP, Gen Counsel & Secretary Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,562 -- 4,562
Dec 17, 2007
SVP, Gen Counsel & Secretary
SVP, Gen Counsel & Secretary Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 45,438 -- 45,438
Dec 17, 2007
VP, Controller and Asst. Treas
VP, Controller and Asst. Treas Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,562 -- 4,562
Dec 17, 2007
VP, Controller and Asst. Treas
VP, Controller and Asst. Treas Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,438 -- 15,438
Dec 17, 2007
SVP, Clinical Development
SVP, Clinical Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,562 -- 4,562
Dec 17, 2007
SVP, Clinical Development
SVP, Clinical Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,438 -- 25,438
Dec 17, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,562 -- 4,562
Dec 17, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,438 -- 25,438
Dec 17, 2007
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 250,000 -- 250,000
Dec 17, 2007
SVP, Research & Devel Sciences
SVP, Research & Devel Sciences Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,562 -- 4,562

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.